The first question would be in which phase does the inconjunct occur? The next step is then to interpret the specific meaning of the inconjunct in the context of the phase it is in with the nn, also remembering that it will also be semi sextile the sn.
Here is an excerpt from my book on the inconjunct:
The inconjunct within the gibbous phase correlates to the need to become aware of a special purpose that the soul is meant to fulfill, and the crisis in aligning with the appropriate actions that are neccesary in order to fulfill that purpose. Thus it has a lot to do with "getting out of one's own way", "letting go and letting god" and "taking it one step at a time". Until the inconjunct is integrated, it can manifest as an angst that there's something to do but "I just don't know how or what to do". It is necessary in this aspect for a soul to just show up. This aspect can produce a deep humility and self knowledge. A good analogy for this aspect would be a person who is faced with various tasks to fulfill; the fulfillment of which requires hard work and a significant degree of “know how”. Thus instead of feeling overwhelmed by how much there is to do and comparing oneself to others who are already doing a better job, the soul just does what it can without creating unnecessary stress. In so doing, the path literally unfolds on its own.
The inconjunct that occurs within the full phase necessitates the soul to pay attention to its environment and showing up in the ways that are needed of the soul. The challenge in this phase is overcoming the resistance to actually offering oneself in the way that is needed, as opposed to the way the soul wants to be needed. The essence of the full phase is balance within the context of socialization. Thus this soul must become aware of what it can and cannot do within its society. If the soul does not listen to what is needed of itself then the soul will be faced with a perpetual feeling of “annoyance” that it just doesn’t feel like it is doing the work it is meant to do. This aspect can produce a great degree of embarrassment. Ultimately a soul can develop social humility through the confrontations created with its social reality.
For example Pluto in the second house with the north node in the 7th, this creates a crisis between the need to engage in relationship with the unconscious impulse and deep security need to be entirely self sufficient unto oneself. The crisis that then develops is where a soul continuously faces the emotional crisis of where it is simply not able to be dependent solely on itself - noting that the sn in this case is in the 1st house, implying the core evolutionary intention has been enacted in the past by remaining independent and alone.
The challenge is that we're looking at Pluto which means there will not be a conscious awareness of this dynamic, only a growing awareness of the fact that there are unresolved relationship needs and challenges around sharing that keep on coming up within the soul's relationships.
This is the stressful nature of any inconjunct involving Pluto and the nodes. In this case, the soul needs to adjust appropriately and learn how to share, learn how to incorporate human relationships into its life - forcing it out of the well (8th house polarity). This requires the soul to simply do the best it can, to be in relationship, to share itself as best as it can, and not isolate itself (gibbous phase inconjunct). This way the soul will be attracting opportunities for growth and evolution.